General Information

  • ID:  hor000140
  • Uniprot ID:  P63181(1-16)
  • Protein name:  Cerebellin-1
  • Gene name:  CBLN1
  • Organism:  Sus scrofa (Pig)
  • Family:  Cerebellins family
  • Source:  animal
  • Expression:  Localized in the Purkinje cells. Cerebellin and [des-Ser1]-cerebellin are equally abundant.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0050808 synapse organization; GO:0099558 maintenance of synapse structure; GO:1905703 negative regulation of inhibitory synapse assembly
  • GO CC:  GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0016020 membrane; GO:0045202 synapse; GO:0045211 postsynaptic membrane

Sequence Information

  • Sequence:  SGSAKVAFSAIRSTNH
  • Length:  16(1-16)
  • Propeptide:  SGSAKVAFSAIRSTNH
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of
  • Mechanism:  Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P63181-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P63181-F1.pdbhor000140_AF2.pdbhor000140_ESM.pdb

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Physical Information

Mass: 190052 Formula: C69H113N23O23
Absent amino acids: CDELMPQWY Common amino acids: S
pI: 11.65 Basic residues: 3
Polar residues: 7 Hydrophobic residues: 6
Hydrophobicity: -15.63 Boman Index: -2963
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 61.25
Instability Index: 2213.75 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2760624
  • Title:  Purification and Characterisation of Cerebellins From Human and Porcine Cerebellum